Arole of Cyfra 21-1 among Tumormarkers for Non-small-celllung Cancer
نویسنده
چکیده
Lung cancer is the most common cancer worldwide. More than 1,000,000 new cases are registered each year. Therefore, it is not surprising that it has become a global problem, and a major focus of interest of thoracic oncologists onbothhemispheres. The aim of this assay is to rewiew the main characteristics of available tumormarkers used inNSCLC. CYFRA21-1 shows the best sensitivity inNSCLCandhigher sensitivity for squamous cell carcinoma thanotherhistological subtypes, a good correlation with disease extent, and a strong specificity in non-malignant lung diseases. Before any treatment, CYFRA21 – 1 shows the highest sensitivity for squamous cell carcinoma when compared to CEA, NSE, CA 19-9, CA 15-3 and CA 125. Therefore, CYFRA 21-1 is the marker of first choice in NSCLC. However, this marker is not suitable forearly diagnosis ofNSCLC. Combinations of markers, identified either by standard immunohistochemical techniques orbymore novel complementaryDNAarrays mayprovequite useful fordiagnosis and treatment of lung cancer.
منابع مشابه
Preoperative CYFRA 21-1 levels as a prognostic factor in c-stage I non-small cell lung cancer.
OBJECTIVE The clinical importance of preoperative CYFRA 21-1 measurement in early-stage non-small cell lung cancer (NSCLC) is still unclear. The aim of this study is to clarify the prognostic value of preoperative CYFRA 21-1 levels in clinical stage (c-stage) I NSCLC. METHODS The records of 101 c-stage I NSCLC patients who had undergone complete resection were analyzed to correlate preoperati...
متن کاملCyfra 21-1 as a biologic marker of non-small cell lung cancer. Evaluation of sensitivity, specificity, and prognostic role.
BACKGROUND Cytokeratins are epithelial markers whose expression is not lost during malignant transformation. Cyfra 21-1 is a cytokeratin-19 fragment that is soluble in serum and may be a useful circulating tumor marker. STUDY OBJECTIVE The aims of this study were (1) to confirm sensitivity and specificity of Cyfra 21-1 in detecting non-small cell lung cancer (NSCLC) and especially the squamou...
متن کاملCYFRA 21-1 as a tumour marker for bronchogenic carcinoma.
Despite extensive research, the role of the commonly employed tumour markers in the diagnosis of lung carcinoma is yet to be clarified. The utility of a new marker, CYFRA 21-1, in the preoperative evaluation of patients with bronchogenic carcinoma was investigated. CYFRA 21-1 was determined with a radiometric assay in serum of 280 patients with lung cancer and 208 patients with various nonmalig...
متن کاملPrognostic value of serum cytokeratin 19 fragments (Cyfra 21-1) in patients with non-small cell lung cancer
The role of serum CYFRA 21-1 level in patients with non-small cell lung cancer (NSCLC) remains to be defined. To re-evaluate the impact of serum CYFRA 21-1 in NSCLC survival, we performed this meta-analysis. Databases were searched to identify relevant studies reported after the publication of a meta-analysis in 2004. Totally, 31 studies with 6394 patients were included in this meta-analysis. T...
متن کاملPreoperative CYFRA 21-1 and CEA as prognostic factors in patients with stage I non-small cell lung cancer.
PURPOSE This study investigated the preoperative serum levels of CYFRA 21-1 and CEA as prognostic factors in patients with stage I non-small cell lung cancer. SUBJECTS This study evaluated 341 patients who had undergone a complete resection for stage I NSCLC between 2002 and 2008. RESULTS The patients included 193 males and 148 females. The mean age of the patients was 69.2 years (range: 19...
متن کامل